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Eastern Mediterranean Health Journal

Print version ISSN 1020-3397


SALEH, A. et al. Serum levels of astroglial S100-beta and neuron-specific enolase in hepatic encephalopathy patients. East. Mediterr. health j. [online]. 2007, vol.13, n.5, pp. 1114-1123. ISSN 1020-3397.

To find a reliable, noninvasive method for the diagnosis of cognitive impairment in patients with hepatic cirrhosis we measured serum levels of astroglial S100b and neuron-specific enolase in cirrhotic patients with and without hepatic encephalopathy (HE). S100b levels showed a significant increase in groups with HE stage 1 and 2 compared to both control and cirrhosis patients. However serum neuron-specific enolase levels were not significantly different between the studied groups. S100b levels had a specificity of 91.3% and sensitivity of 51.7% for detection of HE from cirrhosis. Serum S100b may be a useful surrogate marker for the diagnosis of mild cognitive impairment in cirrhotic patients before they progress to more advanced stages of HE.

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